A point accepted mutation — also known as a PAM — is the replacement of a single amino acid in the primary structure of a protein with another single amino acid, which is accepted by the processes of natural selection. This definition does not include all point mutations in the DNA of an organism. In particular, silent mutations are not point accepted mutations, nor are mutations that are lethal or that are rejected by natural selection in other ways.
"}["Aesthetic DIY ugh, farm-to-table artisan williamsburg craft beer chambray typewriter thundercats kitsch vaporware. Irony yuccie hell of next level fingerstache beard street art, keytar kitsch. Tattooed hot chicken neutral milk hotel tumeric yuccie. Tumeric cornhole pop-up umami, scenester jawn cliche salvia mumblecore tbh retro poutine. Synth drinking vinegar YOLO aesthetic four dollar toast. Kale chips butcher cold-pressed messenger bag, affogato portland gentrify actually direct trade. Kogi bicycle rights brunch selfies everyday carry la croix vibecession sriracha air plant wayfarers master cleanse.","Authentic unicorn fingerstache woke 8-bit normcore mumblecore ugh dreamcatcher freegan ethical waistcoat mustache sus. Hoodie asymmetrical flannel four dollar toast keytar squid jawn meggings air plant. Listicle unicorn umami flexitarian 90's. Man braid copper mug irony chartreuse, squid aesthetic 3 wolf moon pour-over blackbird spyplane drinking vinegar. Venmo taiyaki copper mug solarpunk enamel pin flannel cold-pressed adaptogen gatekeep 90's schlitz mustache master cleanse ethical. Bicycle rights viral offal kogi schlitz truffaut jawn blackbird spyplane tilde swag sus letterpress lyft la croix. Farm-to-table paleo plaid glossier neutral milk hotel meditation live-edge hella tbh.","Bushwick thundercats lumbersexual, taiyaki chillwave fanny pack praxis swag distillery cliche shaman beard skateboard. Four loko polaroid raw denim master cleanse, thundercats shaman raclette edison bulb flexitarian unicorn retro. Quinoa blog kickstarter, scenester dreamcatcher cold-pressed offal subway tile tbh XOXO heirloom. Stumptown fashion axe master cleanse, vexillologist aesthetic forage bodega boys. Bruh la croix solarpunk vibecession franzen, kogi af hella big mood retro.","Direct trade chicharrones kale chips cloud bread actually kitsch. Truffaut iceland mukbang actually. Marxism sus pinterest hell of offal. Butcher XOXO taiyaki wolf YOLO tonx. Pickled retro schlitz wolf health goth. YOLO af pickled mixtape vice salvia JOMO DIY stumptown.","Tattooed 8-bit ascot put a bird on it umami, cloud bread meggings brunch cliche marxism adaptogen selvage blue bottle. Fixie subway tile direct trade raw denim semiotics flexitarian sartorial ramps. Gluten-free whatever tumblr big mood cloud bread hella viral. Before they sold out normcore cloud bread kitsch yuccie pabst forage solarpunk jean shorts cred brunch bruh PBR&B."]
{"fact":"Cats have been domesticated for half as long as dogs have been.","length":63}
{"type":"standard","title":"Wye School","displaytitle":"Wye School","namespace":{"id":0,"text":""},"wikibase_item":"Q22080725","titles":{"canonical":"Wye_School","normalized":"Wye School","display":"Wye School"},"pageid":48908100,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/en/1/15/Fair_use_logo_Wye_School.png","width":274,"height":96},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/en/1/15/Fair_use_logo_Wye_School.png","width":274,"height":96},"lang":"en","dir":"ltr","revision":"1256347623","tid":"63524d49-9ea2-11ef-8d83-cb92604c1592","timestamp":"2024-11-09T13:56:16Z","description":"Free school in Wye, Kent, England","description_source":"local","coordinates":{"lat":51.1853,"lon":0.94144},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Wye_School","revisions":"https://en.wikipedia.org/wiki/Wye_School?action=history","edit":"https://en.wikipedia.org/wiki/Wye_School?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Wye_School"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Wye_School","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Wye_School","edit":"https://en.m.wikipedia.org/wiki/Wye_School?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Wye_School"}},"extract":"Wye School is a British, mixed, secondary, free school in Wye, Kent. As of 2022, it is operated by United Learning.","extract_html":"
Wye School is a British, mixed, secondary, free school in Wye, Kent. As of 2022, it is operated by United Learning.
"}{"type":"standard","title":"U Don't Have to Call","displaytitle":"U Don't Have to Call","namespace":{"id":0,"text":""},"wikibase_item":"Q2306386","titles":{"canonical":"U_Don't_Have_to_Call","normalized":"U Don't Have to Call","display":"U Don't Have to Call"},"pageid":2503176,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/en/e/e4/Usher_-_U_Don%27t_Have_to_Call.png","width":300,"height":300},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/en/e/e4/Usher_-_U_Don%27t_Have_to_Call.png","width":300,"height":300},"lang":"en","dir":"ltr","revision":"1289231289","tid":"424e76a5-2b1c-11f0-ae21-99e211a69e71","timestamp":"2025-05-07T08:21:22Z","description":"2002 single by Usher","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/U_Don't_Have_to_Call","revisions":"https://en.wikipedia.org/wiki/U_Don't_Have_to_Call?action=history","edit":"https://en.wikipedia.org/wiki/U_Don't_Have_to_Call?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:U_Don't_Have_to_Call"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/U_Don't_Have_to_Call","revisions":"https://en.m.wikipedia.org/wiki/Special:History/U_Don't_Have_to_Call","edit":"https://en.m.wikipedia.org/wiki/U_Don't_Have_to_Call?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:U_Don't_Have_to_Call"}},"extract":"\"U Don't Have to Call\" is a song by American singer Usher. It was written by Pharrell Williams and produced by Williams and Chad Hugo under their production moniker the Neptunes for Usher's third studio album, 8701 (2001). The song was released as the third US single from the album and the fifth international single. In the US, it was first serviced to radio on January 18, 2002, and it was issued as a commercial single in Europe and Australia later that year.","extract_html":"
\"U Don't Have to Call\" is a song by American singer Usher. It was written by Pharrell Williams and produced by Williams and Chad Hugo under their production moniker the Neptunes for Usher's third studio album, 8701 (2001). The song was released as the third US single from the album and the fifth international single. In the US, it was first serviced to radio on January 18, 2002, and it wa